Brain Circuitry That Drives Drug-seeking Compulsion Identified

In experiments with rats, researchers have identified the change in brain circuitry that drives development of a compulsion to seek drugs, even when that compulsion is self-destructive. The researchers demonstrated the function of the circuitry by selectively switching off drug-seeking in the animals. They said their findings show the key role of the brain region, known as the striatum, which is a region activated by reward.

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